郑国栋

发布者:spkx发布时间:2018-03-23浏览次数:5761


郑国栋:博士,教授,首批江西省政府发展研究中心特约研究员;199810-20077月在日本攻读硕士、博士,博士后及日本企业工作。博士期间发表8篇论文,其中4SCI,被SCI引用了三百多次。回国后,在江西农业大学食品科学与工程学院工作;排名第一获2013年度江西省自然科学奖三等奖一项;发表了学术论文90余篇,其中第一作者或通讯作者SCI/EI论文30多篇;主持科研项目十多项,其中国家自然科学基金3项;主要研究方向是天然产物分离鉴定及生物功能研发。

奖励

江西省自然科学奖三等奖,2013,排名第一

主持课题

1、主持在研国家自然基金地区项目,《基于菝葜多酚类化合物对肠道菌群代谢产物与脂类代谢的相关性研究》(2021.01-2024.12)项目编号:82060165

2、主持完成国家自然基金地区项目,《基于AMPK信号通路研究菝葜黄酮提取及调控脂类代谢的分子机制》(2018.01-2021.12)项目编号:81760157

3、主持完成国家自然基金地区项目,《儿茶素和咖啡碱组合对小鼠和 3T3-L1 细胞的脂肪代谢分子机制的研究》(2012.01-2015.12)项目编号:31160320

4、主持中央引导地方科技发展专项资金项目子课题,《永新县优质茶叶生产示范推广项目》(2018.07-2020.06)项目编号:2018ZDF40010

5、主持完成江西省科技厅科技支撑重大项目,《夏秋茶品质提升及综合利用》(2016.01-2017.12)项目编号:S2016NYZDF0071

6、主持完成江西省星火计划项目,《万亩有机茶产品提升机加工》(2014.01-2015.12)项目编号:20141BBF61088

7、主持完成江西省自然科学基金项目,《咖啡碱和绿原酸对高脂饮食诱导肥胖小鼠脂肪代谢相关基因和蛋白表达的影响》(2014.01-2015.12)项目编号:20142BAB204003

 

近五年主要通讯作者的论文(*为通讯作者)

1. XinLi#, WeiliJin, WenkaiZhang, GuodongZheng*. The inhibitory kinetics and mechanism of quercetin-3-O-rhamnoside and chlorogenic acid derived from Smilax china L. EtOAc fraction on xanthine oxidase [J]. International Journal of Biological Macromolecules, 2022, 213: 447-455. https://doi.org/10.1016/j.ijbiomac.2022.05.188

2. Li Kong#, Meng Xu, Licong Yang, Shanshan Liu, Guodong Zheng*. Smilax chinapolyphenols stimulate browning via β3-adrenergic receptor/AMP-activated protein kinase α signaling pathway in 3T3-L1 adipocytes [J]. The American Journal of Chinese Medicine, 2022, 50(5): 1-15, DOI: 10.1142/S0192415X22500550

3. Meng Xu#, Hui Xue, Gaoxiang Qiao, Mingfu Liao, Li Kong, Qingfeng Zhang, Lezhen Lin, Licong Yang*, Guodong Zheng*. Regulating the imbalance of gut microbiota by Smilax china L. polyphenols to alleviate dextran sulfate sodium-induced inflammatory bowel disease[J]. The American Journal of Chinese Medicine, 2022, 50 (2):553-568.DOI: 10.1142/S0192415X22500215

4. XinLi#,LuluChu,ShanshanLiu,WenkaiZhang,LezhenLin,GuodongZheng*.Smilax china L. flavonoid alleviates HFHS-induced inflammation by regulating the gut-liver axis in mice [J]. Phytomedicine, 2022, 95: 153728. DOI:10.1016/j.phymed.2021.153728

5. Changjiang Li#, Na Wang#, Guodong Zheng*, Licong Yang*. Oral administration of resveratrol-selenium-peptide nanocomposites alleviates Alzheimer’s disease-like pathogenesis by inhibiting Aβ aggregation and regulating gut microbiota [J]. ACS Applied Materials & Interfaces, 2021,13:46406-46420. https//doi.org/10.1021/acsami.1c14818

6. Xin Li#, Licong Yang,Jingen Li, Lezhen Lin, Guodong Zheng*. A flavonoid-rich Smilax china L. extract prevents obesity by upregulating the adiponectin-receptor/AMPK signalling pathway and modulating the gut microbiota in mice [J].Food & Function, 2021, 12, 5862-5875. DOI: 10.1039/D1FO00282A

7. Li Kong#, Meng Xu#, Yangyang Qiu, Qingfeng Zhang, Licong Yang*, Guodong Zheng*. Chlorogenic acid and caffeine combination attenuates adipogenesis by regulating fat metabolism and inhibiting adipocyte differentiation in 3T3-L1 cells [J].Journal of Food Biochemistry, 2021, 45(7):e13795. DOI: 10.1111/jfbc.13795

8. Xin Li#, Licong Yang#, Meng Xu, Gaoxiang Qiao, Changjiang Li, Lezhen Lin, Guodong Zheng*.Smilax china L. polyphenols alleviates obesity and inflammation by modulating gut microbiota in high fat/high sucrose diet-fed C57BL/6J mice [J]. Journal of Functional Foods, 2021,77: 104332. doi.org/10.1016/j.jff.2020.104332

9Licong Yang#, Yanping Zhu, Shusheng Zhong,Guodong Zheng*. Astilbin lowers the effective caffeine dose for decreasing lipid accumulation via activating AMPK in high-fat diet-induced obese mice [J].Jouenal of the Science of Food and Agriculture, 2021, 101: 573-581, DOI 10.1002/jsfa.10669

10. MengXu#, Licong Yang#, YanpingZhu, Mingfu Liao, Lulu Chu, Xin Li, Lezhen Lin, Guodong Zheng*. Collaborative effects of chlorogenic acid and caffeine on lipid metabolism via AMPKα-LXRα/SREBP-1c pathway in High-Fat Diet-Induced obese mice [J]. Food & Function, 2019, 10: 7489-7497. DOI: 10.1039/C9FO00502A

11. Meng Xu#, Hui Xue, Xin Li, Yan Zhao, Lezhen Lin, Licong Yang*,Guodong Zheng*. Chemical composition, antibacterial properties, and mechanism of Smilax china L. polyphenols [J].Applied Microbiology and Biotechnology, 2019, 103: 9013-9022. doi.org/10.1007/s00253-019-10100-0

12. LuluChu#, LicongYang*, JingenLi, LezhenLin, GuodongZheng*. Effect of Smilax china L. starch on the gel properties and interactions of calcium sulfate-induced soy protein isolate gel [J]. International Journal of Biological Macromolecules, 2019, 135: 127-132.

13. Lulu Chu#, Licong Yang*, Lezhen Lin, Jing Wei, Na Wang, Meng Xu, Gaoxiang Qiao, Guodong Zheng*. Chemical composition, antioxidant activities of polysaccharide from Pine needle (Pinus massoniana) and hypolipidemic effect in high-fat diet-induced mice [J]. International Journal of Biological Macromolecules, 2019, 125: 445-452doi.org/10.1016/j.ijbiomac.2018.12.082

14. Licong Yang#, Yan Zhao, Yongfang Pan, Dongming Li, Guodong Zheng*. Dietary Supplement of Smilax china L. Ethanol Extract Alleviates the Lipid Accumulation by Activating AMPK pathways in High-Fat Diet Fed Mice [J]. Nutrition & Metabolism, 2019, 16, 6. doi.org/10.1186/s12986-019-0333-z

15. Licong Yang#, Na Wang, Guodong Zheng*. Enhanced effect of combining chlorogenic acid on selenium nanoparticles in inhibiting amyloid β aggregation and reactive oxygen species formation In Vitro[J]. Nanoscale Research Letters, 2018, 13:303, doi.org/10.1186/s11671-018-2720-1

16. Licong Yang#, Wenjun Wang, Jiguang Chen, Na Wang, Guodong Zheng*. A comparative study of resveratrol and resveratrol-functional selenium nanoparticles: Inhibiting amyloid β aggregation and reactive oxygen species formation properties[J]. Journal of Biomedical Materials Research Part A, 2018, 106A:3034-3041.doi: 10.1002/jbm.a.36493 

17. Ji-Luan Liu#, Li-Cong Yang#, Xiao-Juan Zhu, Wen-Jun Wang, Guo-Dong Zheng*. Combinational effect of pine needle polysaccharide and Kudzu flavonoids on cell differentiation and fat metabolism in 3T3-L1 cells[J]. Food Science and Technology Research, 2018, 24 (5), 903-910, doi.org/10.3136/fstr.24.903

18. Yan Zhao#, Licong Yang#, Zhanwang Huang, Lezhen Lin, Guodong Zheng*, Synergistic effects of caffeine and catechins on lipid metabolismin chronically fed mice via the AMPactivated protein kinasesignaling pathway[J].European Journal of Nutrition, 2017, 56(7): 2309-2318. doi.org/10.1007/s00394-016-1271-4

19. XiaojuanZhu#, Licong Yang, Lezhen Lin,Guodong Zheng*. Combination therapy with catechins and caffeine inhibits fat accumulation in 3T3-L1 cells[J]. Experimental and Therapeutic Medicine, 2017, 13, 688-69, DOI10.3892/etm.2016.3975

20. 李欣#,潘永芳,王娜,杨丽聪*,郑国栋*。菝葜醇提物对小鼠脂肪代谢酶的影响[J].江西农业大学学报,2020422:385-390

21. 乔高翔#,杨丽聪,郑国栋*. 菝葜根茎色素的提取及稳定性研究[J].食品研究与开发,2020412):107-112

22. 李长江#,朱珊珊,王娜,聂梦娇,郑国栋*,杨丽聪*Vc@SeNPs抗氧化活性评价及其对鲜切苹果品质的影响[J].食品与发酵工业,2020,4613):174-181.

23. 褚路路,杨丽聪,郑国栋*。响应面法优化大白菜腌制条件[J].食品工业科技,20183914):147-151

24. 朱艳萍#,杨丽聪,林乐珍,淦述翔,郑国栋*。咖啡碱和绿原酸对高脂饮食小鼠体重、脂类沉积及肝脏脂质代谢基因表达的影响[J]。食品科学,2017,389):162-167

25. 金伟丽,杨丽聪,许海霞,林乐珍,郑国栋*。珊瑚菌三萜的微波辅助提取工艺研究[J]。西北农林科技大学学报(自然科学版),2017455):197-203

26. 魏晶、叶芝红、林乐珍、郑国栋*。响应面法优化超声波提取平卧菊三七多糖工艺[J]。食品研究与开发,20173819):24-28